PENINGKATAN KELARUTAN EKSTRAK ETANOL DAUN SIRIH MERAH (PIPER CROCATUM RUIZ & PAV.) MELALUI KOMPLEKSASI DENGAN β-SIKLODEKSTRIN

https://doi.org/10.62085/ajk.v4i2.232

Authors

  • Yola Desnera Putri Sekolah Tinggi Farmasi Indonesia
  • Princesa Elnovita Tierra Sekolah Tinggi Farmasi Indonesia
  • Sohadi Warya Sekolah Tinggi Farmasi Indonesia
  • Adit Andriyannto Sekolah Tinggi Farmasi Indonesia

Keywords:

β-cyclodextrin, kneading, red betel leaf (Piper crocatum), solubility

Abstract

Red betel leaves (Piper crocatum Ruiz & Pav.) are rich in secondary metabolites, particularly flavonoids, which exhibit pharmacological potential such as antioxidant and antidiabetic properties. However, the low solubility of the extract poses a major challenge in drug formulation development. This study was designed to enhance the solubility of ethanol extract from red betel leaves by forming inclusion complexes with β-cyclodextrin using the kneading method, and further developing it into instant-dissolving granules. Extraction was performed via maceration technique with 70% ethanol as the solvent. Complexes were prepared by kneading at ratios of 1:1, 1:2, and 1:3 (extract:β-cyclodextrin). The resulting complexes were tested for solubility and formulated into granules through wet granulation. The extraction yielded 10.92% render. Kneading complex formation successfully increased solubility to 16.092% (F1), 27.844% (F2), and 36.302% (F3). Evaluation of the granules' physical properties showed parameters meeting standard requirements. The study concludes that β-cyclodextrin incorporation via kneading is effective in improving the solubility of red betel leaf extract and producing granules with optimal physical characteristics.

Author Biographies

Princesa Elnovita Tierra, Sekolah Tinggi Farmasi Indonesia

Departemen Farmasetika, Sekolah Tinggi Farmasi Indonesia, Bandung, Jawa Barat 40266, Indonesia

Sohadi Warya, Sekolah Tinggi Farmasi Indonesia

Departemen Farmasetika, Sekolah Tinggi Farmasi Indonesia, Bandung, Jawa Barat 40266, Indonesia.

Adit Andriyannto, Sekolah Tinggi Farmasi Indonesia

Departemen Farmasetika, Sekolah Tinggi Farmasi Indonesia, Bandung, Jawa Barat 40266, Indonesia. 

Dimensions

Published

2026-07-23

How to Cite

Putri, Y. D., Tierra, P. E., Warya, S., & Andriyannto, A. (2026). PENINGKATAN KELARUTAN EKSTRAK ETANOL DAUN SIRIH MERAH (PIPER CROCATUM RUIZ & PAV.) MELALUI KOMPLEKSASI DENGAN β-SIKLODEKSTRIN . ASSYIFA : Jurnal Ilmu Kesehatan, 4(2), 584–592. https://doi.org/10.62085/ajk.v4i2.232

Issue

Vol. 4 No. 2 (2026)

Section

Articles
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